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Bilu Huang

Founding Scientist & Theoretical Biologist

Bilu Huang

Pioneering Theoretical Biologist

Bilu Huang is the founding scientist of the Bilu Huang Institute for Aging Research and Fuzhuang Therapeutics. With over three decades of dedicated research, he has developed groundbreaking theoretical frameworks that challenge conventional understanding of aging.

Key Contributions

  • Founder of the TRCS Model of telomere DNA and ribosomal DNA co-regulation model for cell senescence
  • Develop precision theoretical approaches to aging research and age-related diseases
  • Founded Fuzhuang Therapeutics to translate theoretical insights into practical interventions
Full Biography
My mission is not to just slow aging for longevity, but rejuvenation back to my most vigourous 30s! Time flies away, relentless as the years. Every news of death stirs in me a surge against aging. I will gather humanity's most cutting-edge biotechnologies, develop theories of pinpoint precision, challenge the death and race against time! — Bilu Huang Theoretical Biologist, Founding Scientist, Fuzhuang Tx

Research Focus

We are committed to revealing the fundamental mechanisms of aging and age-related diseases with theoretical pinpoint precision.

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Cellular Aging Mechanisms

Exploring telomeres, rDNA, and other fundamental components of cellular aging processes.

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Neurodegenerative Diseases

Research on Alzheimer's, Parkinson's, and other age-related neurodegenerative conditions.

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Cancer and Aging

Investigating the molecular links between aging processes and cancer development.

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The TRCS Model

Our latest model of telomere DNA and ribosomal DNA co-regulation model for cell senescence.

TRCS Molecular Mechanism Diagram

Individual Aging Mechanism

TRCS Overall Framework

The TRCS Model

My research shows that aging is essentially a genetic program driven by telomeres and/or rDNA shortening through the p53 pathway, rather than the accumulation of damage. Individual aging results from replicative senescence of adult stem cells; and that cellular senescence is co-regulated by telomeres and rDNA through the p53 pathway. Moreover, the 11 other classic hallmarks of aging are downstream events regulated by p53 upregulation after telomere and rDNA shortening. From the perspective of first principles, the lifespan of a species is determined by the shortening rate of telomeres and rDNA arrays.

Bilu Huang

Bilu Huang

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Latest Publications

Our peer-reviewed academic achievements

Journal Cover
Aging and Disease
2025 Review

Causality of Aging Hallmarks

Bilu Huang, Xiaowen Hu

This paper introduces a groundbreaking theoretical framework that challenges conventional understanding of cellular aging. Our research demonstrates how telomere dynamics interact with ribosomal DNA stability in a previously unrecognized regulatory circuit.

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DOI: 10.14336/AD.2025.0541
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Institute News

Stay updated with our latest developments and announcements

New paper published in Nature Aging
2025-11-20 Collaboration

New partnership with leading bioinformatics team

We are excited to announce a new collaborative research initiative with the Mango Research Team to explore the connections between aging and cancer.

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New paper
2025-10-24 Academic Activity

Speech at Global Summit on Aging and Longevity 2025

Bilu Huang invited to share the TRCS model of telomere and rDNA co-regulation of cell senescence in Tokyo, Japan.

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New paper published in Nature Aging
2025-09-20 Interview

Progress, Potential, and Possibilities Show

Exclusive interview with Bilu Huang on his vision for tackling some of humanity's most challenging issues.

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Contact Us

Have a question for the Bilu Huang's Aging Institute?

Please reach out to:

Ms. Clair Xiaowen Hu

Manager of Communications & Outreach

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Xinyang Town, Youxi County, Sanming City

Fujian Province, China, 365118

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xiaowenhu@fuzhuangtx.com

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Team Photo Outside the Institute